Can The Paleo Diet Reverse Gilbert's Syndrome? | The Paleo Diet®
noun_Search_345985 Created with Sketch.

Try The Paleo Diet®!

Learn more. Get recipes & meal plans. See the science.

Gilbert's Syndrome: Can a Paleo Diet Reverse An Irreversible Condition?

By Christopher Clark
April 28, 2015
mi_viri/ Shutterstock.com
mi_viri/ Shutterstock.com

Gilbert's Syndrome (GS) is a relatively common condition characterized by increased levels of bilirubin in the blood. Bilirubin is a naturally occurring yellow pigment that forms when red blood cells break down. GS is a genetic condition whereby a single gene mutation prevents the liver from properly removing bilirubin from the blood. Between 5 – 10% of the population may have GS, but around one-third don’t have symptoms.1

Normally, when red blood cells reach the end of their approximately 120 day life span, they break down into bilirubin. The liver then processes the bilirubin, readying it for elimination. Bilirubin gives urine its yellow tinge and stools their dark brown color. For those afflicted by GS, however, the liver sometimes processes bilirubin at a slower rate. Buildups can occur, sometimes resulting in jaundice (a yellowing of the eyes and skin).

GS is regarded as common and harmless, but is associated with numerous unpleasant symptoms, including fatigue, itching, gastrointestinal symptoms, and increased risk for gallstones. Because it’s a hereditary condition, scientists have generally presumed there is no cure. But could The Paleo Diet® or other dietary interventions help?

Can The Paleo Diet Reverse Gilbert's Syndrome?

A Hungarian researcher team started investigating this question several years ago. In April 2015, they published their findings in the American Journal of Medical Case Reports.2 While their study involved just one patient, the researchers were successful in reversing her GS symptoms.

In 2006, doctors diagnosed the patient, then 30 years old, with GS. At that time, she had a 10 year history of frequent migraines (about three/month) and a 10 year history of dermatitis. She also exhibited persistent fatigue, constipation, and yellowing of the eyes.

In 2010, she began following The Paleo Diet excluding dairy, grains, legumes, refined carbohydrates, and vegetable oils from her diet. After one year, her bilirubin levels returned to the normal range, her jaundice and constipation resolved, and her migraines reduced to roughly one every two months. Her fatigue and dermatitis, however, persisted.

She followed The Paleo Diet for a total of 20 months. On the advice of the researchers, she then switched to a ketogenic version of The Paleo Diet. Ketogenic diets, of course, involve greatly reduced carbohydrate consumption. Her Paleo-keto diet, which she maintains to this day, includes mostly animal fat, meat, eggs, organ meats, and less than 30% vegetables and fruit. At least twice per week she consumed organ meats. Since beginning her Paleo-keto diet, her fatigue has disappeared, as has her dermatitis. Her migraines have further reduced to roughly twice per year.

Of course, this n=1 study doesn’t prove the Paleo/Paleo-keto diet cures GS. Nevertheless, the study is significant because it’s the first documented case of successfully treating GS through dietary intervention. This study could potentially open the door to larger studies, which could test the hypothesis that Paleo/Paleo-keto can cure GS (or greatly mitigate its symptoms). And on an individual level, GS patients, with the help of their physicians, could implement Paleo/Paleo-keto principals and perhaps improve their conditions.

Can The Paleo Diet Protect Against Chronic Diseases?
By Dr. Marc Bubbs

References

[1] Owens, D, et al. (June 1975). “Population studies on Gilbert's syndrome.” Journal of Medical Genetics, 12(2). Retrieved from //www.ncbi.nlm.nih.gov/pubmed/1142378

[2] Tóth, C, and Zsófia, C. (April 2015). “Gilbert's Syndrome Successfully Treated with the Paleolithic Ketogenic Diet.” American Journal of Medical Case Reports, 3(4). Retrieved from //pubs.sciepub.com/ajmcr/3/4/9/

Even More Articles For You

Staying on Track With the Paleo Diet While Traveling
Many people jump off the Paleo wagon as soon as they begin to travel. Learn how you can stay on track with healthy Paleo foods and intermittent fasting in today's blog!
By Stephanie Vuolo
The Beginner’s Guide to Shopping at a Farmer’s Market
If you’ve never enjoyed a farmer's market before, here are some things you should know to help shop.
By Aimee McNew
Dr. Cordain's Rebuttal to U.S. News and World Report Top 20 Diets
Looking for The Paleo Diet® food ideas? Be sure to visit our website for the latest & greatest Paleo Diet recipes, articles & more. Check out our blog!
By Loren Cordain, Ph.D.
Paleo Leadership
 
Trevor Connor
Trevor Connor

Dr. Loren Cordain’s final graduate student, Trevor Connor, M.S., brings more than a decade of nutrition and physiology expertise to spearhead the new Paleo Diet team.

Mark J Smith
Dr. Mark J. Smith

One of the original members of the Paleo movement, Mark J. Smith, Ph.D., has spent nearly 30 years advocating for the benefits of Paleo nutrition.

Nell Stephenson
Nell Stephenson

Ironman athlete, mom, author, and nutrition blogger Nell Stephenson has been an influential member of the Paleo movement for over a decade.

Loren Cordain
Dr. Loren Cordain

As a professor at Colorado State University, Dr. Loren Cordain developed The Paleo Diet® through decades of research and collaboration with fellow scientists around the world.