Insulin, Betacellulin, and Estrogens

Insulin, Betacellulin, and Estrogen | The Paleo DietInsulin, Betacellulin, and Estrogens Excerpt

We discovered that bovine insulin (BI) is present in commercially pasteurized milk and infant formulas. We also learned that BI has good oral bioavailability since antibodies to BI are a common phenomenon among children who have consumed infant formula containing cow’s milk. This is very important information for children who have a genetic predisposition for T1D because BI differs from human insulin by only three amino acids. The immune response induced by BI in these children may react with human insulin and lead to ß-cell destruction, especially if children are exposed to infant formula containing cow’s milk before the age of 3 months. This is a period of high intestinal permeability or leaky gut.

As expected, various epidemiological studies have associated cow’s milk consumption with T1D in genetically susceptible children, especially when the initial exposure begins in the first months of life. Thus, exclusively breastfeeding during the first 6 months and avoiding formulas based on cow’s milk is highly recommended.

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