Tag Archives: food addiction

pizza

Photo by Alan Hardman on Unsplash

While there are many popular foods in America, studies have shown that the classic pizza is the most popular. It has had a huge impact on both our dietary habits and our waistlines. [1] Interestingly, pizza has also been studied to be most associated with indicators of addiction. [2] A report by CNN showed that there is a very precise mechanism at play behind the addictive nature of everyone’s favorite carbohydrate source.  Not surprisingly, it’s salt, sugar, and fat—perfectly proportioned—that makes pizza so impossible to resist. [3-7]

As I have noted before in previous articles, food addiction is very real, and very specific. [8-15] That is to say, it is directly related to the fact that the large majority of our modern diet is processed food. But to understand why food addiction is so common today, we must dive into what exactly the term “processed food” means. Simply, it’s food made entirely by humans. Processed foods do not exist in nature; in fact, it’s almost impossible to be truly addicted to any food found in nature. This is not an accident. This is why low-carb cookbooks that focus on real foods tend to help many with weight loss (this is certainly the feedback my cookbook has gotten).

But processed food works differently. As many scientific researchers have noted, food chemists are paid to make some foods irresistible. [16-17] And when I say irresistible, it’s a polite way of saying addictive. That’s quite shocking to read, but not if you’ve been paying attention to big food companies for the last 100 years. Slowly but surely, food manufacturers have increased the amount of sugar, caffeine, salt, fat, and calories in foods. [18] That decision is a cold, economic one, backed by decades of research.

Big food executives know that the more consumers purchase and consume their food, the better off they will be. [19] This means that ramping up the addictiveness is essentially their only long-term option to continue to make higher profits. However, there is a positive side: Due to consumers’ changing habits (largely due to new ideas like The Paleo Diet) and the subsequent increase in demand for healthier foods, big food companies have started to modify what they offer. From a cynical perspective, it seems they are only doing so because there is now money to be made in this segment of the market. Nevertheless, they are providing more nutritious fare.

If one doubts this narrative, all you need to do is take a look at internal documents from soda companies, which call the consumers who drink their products the most “heavy users.” [20] This is the same term that’s used to refer to drug addicts. This is not a compliment, and it’s not an accident. Many executives from Big Tobacco made the leap to the food industry and brought with them deceptive advertising methods and a penchant for unhealthy products. But because addictive, sugary, and obesity-causing food is only chronically toxic, not acutely toxic, it is increasingly difficult to provide meaningful regulation.

The brain’s amygdala is the biological center for food addiction. In this portion of the brain, feelings of happiness are triggered when the right combination and proportions of certain macronutrients are consumed. [21] It is also the area that helps us determine when foods are too cheesy, too salty, or too sugary. Food chemists have figured out how to make foods most palatable and, thus, most addictive along this spectrum of taste. They refer to it as the “bliss point.” [22] If this sounds unsettling, it is.

If you need help reigning in your doughnut consumption, consider the hundreds of lab tests that were performed on that doughnut before it was brought to market. Scientists determined precisely how much sugar to include, for the sole purpose of making you crave another one. This brings us to the addictive and disturbing properties of sugar. It’s simply a white poison, in many respects—albeit one that acts slowly and lacks potency. [23] Nonetheless, it has many disturbing biochemical similarities to alcohol, which is a much more acute toxin. [24] The more sugar we consume, the more we crave it. If we withdraw from sugar, there are withdrawal symptoms. [25]

In fact, some studies have shown that cookies are potentially more addictive than cocaine. [26] While the comparison isn’t particularly fair, one thing is certain: there’s a societal acceptance of both obesity and cookies, whereas cocaine is a social stigma. Yes, the nature of our society makes it okay to eat half of a pizza in one sitting, but not okay to ingest addictive drugs. The truth is that both of these are addictions. It has been interesting to see the obesity pandemic balloon to enormous heights, and simultaneously see the “body positivity” movement take off. [27]

While I have no issue with people having self-esteem, as a personal trainer and nutritionist I’m much more concerned with what obesity is doing to the client’s long-term health. Obesity is, quite literally, deadly.

Which brings us back to that classic slice of pizza.

Let’s break it down and see just how addictive it, as an example of the modern Western diet, can be. Cheese by itself has been shown to be addictive. Add to that bread, which is also addictive. Then throw in some sugar (via sauce) for good measure. It’s the perfect mixture of pleasure for our amygdala.

And let’s not forget the volume of salt in pizza. This is another significant factor in its addictiveness. [28] The CNN report explained how a top sensory scientist has helped companies bring more addictive qualities to pizza, “enhancing” it through food science, to make us want to consumer more of it.

If this sounds a little bit like Darth Vader using the force (i.e. science) for the dark side, you’re right. So, the next time you sit down to have a slice of pizza, think long and hard about how much science went into making it irresistible.

 

References

  1. Devine CM, Nelson JA, Chin N, Dozier A, Fernandez ID. “Pizza is cheaper than salad”: assessing workers’ views for an environmental food intervention. Obesity (Silver Spring). 2007;15 Suppl 1:57S-68S.
  2. Schulte EM, Avena NM, Gearhardt AN. Which foods may be addictive? The roles of processing, fat content, and glycemic load. PLoS ONE. 2015;10(2):e0117959.
  3. Schulte EM, Avena NM, Gearhardt AN. Which foods may be addictive? The roles of processing, fat content, and glycemic load. PLoS ONE. 2015;10(2):e0117959.
  4. Koob GF, Volkow ND. Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry. 2016;3(8):760-73.
  5. Volkow ND, Morales M. The Brain on Drugs: From Reward to Addiction. Cell. 2015;162(4):712-25.
  6. Volkow ND, Wise RA, Baler R. The dopamine motive system: implications for drug and food addiction. Nat Rev Neurosci. 2017;18(12):741-752.
  7. Volkow ND, Wang GJ, Tomasi D, Baler RD. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013;14(1):2-18.
  8. Mies GW, Treur JL, Larsen JK, Halberstadt J, Pasman JA, Vink JM. The prevalence of food addiction in a large sample of adolescents and its association with addictive substances. Appetite. 2017;118:97-105.
  9. Ayaz A, Nergiz-unal R, Dedebayraktar D, et al. How does food addiction influence dietary intake profile?. PLoS ONE. 2018;13(4):e0195541.
  10. Novelle MG, Diéguez C. Food Addiction and Binge Eating: Lessons Learned from Animal Models. Nutrients. 2018;10(1)
  11. Eördögh E, Hoyer M, Szeleczky G. [Food Addiction as a new behavioral addiction]. Psychiatr Hung. 2016;31(3):248-255.
  12. Ziauddeen H, Fletcher PC. Is food addiction a valid and useful concept?. Obes Rev. 2013;14(1):19-28.
  13. Gordon EL, Ariel-donges AH, Bauman V, Merlo LJ. What Is the Evidence for “Food Addiction?” A Systematic Review. Nutrients. 2018;10(4)
  14. Gordon EL, Ariel-donges AH, Bauman V, Merlo LJ. What Is the Evidence for “Food Addiction?” A Systematic Review. Nutrients. 2018;10(4)
  15. Volkow ND, Wang GJ, Tomasi D, Baler RD. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013;14(1):2-18.
  16. Penzenstadler L, Soares C, Karila L, Khazaal Y. Systematic Review of Food Addiction as Measured With the Yale Food Addiction Scale: Implications for the Food Addiction Construct. Curr Neuropharmacol. 2018;
  17. Parylak SL, Koob GF, Zorrilla EP. The dark side of food addiction. Physiol Behav. 2011;104(1):149-56.
  18. Avena NM, Rada P, Hoebel BG. Sugar and fat bingeing have notable differences in addictive-like behavior. J Nutr. 2009;139(3):623-8.
  19. Brownell KD, Warner KE. The perils of ignoring history: Big Tobacco played dirty and millions died. How similar is Big Food?. Milbank Q. 2009;87(1):259-94.
  20. Vartanian LR, Schwartz MB, Brownell KD. Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis. Am J Public Health. 2007;97(4):667-75.
  21. Moore CF, Sabino V, Koob GF, Cottone P. Neuroscience of Compulsive Eating Behavior. Front Neurosci. 2017;11:469.
  22. Spence C, Okajima K, Cheok AD, Petit O, Michel C. Eating with our eyes: From visual hunger to digital satiation. Brain Cogn. 2016;110:53-63.
  23. Stanhope KL. Sugar consumption, metabolic disease and obesity: The state of the controversy. Crit Rev Clin Lab Sci. 2016;53(1):52-67.
  24. Manzo-avalos S, Saavedra-molina A. Cellular and mitochondrial effects of alcohol consumption. Int J Environ Res Public Health. 2010;7(12):4281-304.
  25. Mangabeira V, Garcia-mijares M, Silva MT. Sugar withdrawal and differential reinforcement of low rate (DRL) performance in rats. Physiol Behav. 2015;139:468-73.
  26. Lenoir M, Serre F, Cantin L, Ahmed SH. Intense sweetness surpasses cocaine reward. PLoS ONE. 2007;2(8):e698.
  27. Meldrum DR, Morris MA, Gambone JC. Obesity pandemic: causes, consequences, and solutions-but do we have the will?. Fertil Steril. 2017;107(4):833-839.
  28. Tekol Y. Salt addiction: a different kind of drug addiction. Med Hypotheses. 2006;67(5):1233-4.

The Reality of Food Addiction: Recharged | The Paleo Diet

In one of my post popular articles, I dove deep into the mire of just why so many of us are addicted to food. This subject is fascinating on both a molecular and individual level.1, 2, 3, 4  There are so many factors which go into food addiction.5, 6, 7, 8, 9, 10, 11, 12, 13 And most of them go totally unnoticed, to most people.14, 15, 16, 17, 18, 19, 20, 21, 22 The pervasiveness of advertising, the purposely addictive nature of processed foods, and the stressful nature of modern life is just too much for most of us to stay healthy.23, 24, 25, 26, 27, 28, 29, 30, 31, 32 Of course, new research has emerged on this topic, since an entire calendar year has passed since I wrote my first piece on food addiction – and some of it is quite startling.33, 34, 35, 36, 37, 38, 39, 40,

The Reality of Food Addiction: Recharged | The Paleo Diet

Volkow, Nora D et al. “Overlapping Neuronal Circuits in Addiction and Obesity: Evidence of Systems Pathology.” Philosophical Transactions of the Royal Society B: Biological Sciences 363.1507 (2008): 3191–3200. PMC. Web. 7 Aug. 2015.

But perhaps most troublingly, many scientists are still trying to fight the notion that food addiction even exists.41, 42, 43 I’m alarmed, offended and angry about this continued hemming and hawing (no doubt influenced by industry) – and you should be too. In simplest terms, go ask the average person following a Standard American Diet (SAD) if they feel addicted to food. I would bet everything I own that their answer would be a resounding “yes.”44, 45 No one wants to be obese, and unquestionably some level of addiction is underlying our obesity pandemic.46, 47, 48, 49, 50, 51 52, 53, 54, 55 Certainly there are also other factors, which I’ve also written about, (like leptin resistance) that happen as a result of poor food choices compounded over time.56, 57, 58, 59, 60, 61, 62, 63, 64

The Reality of Food Addiction: Recharged | The Paleo Diet

Agrawal, Rahul, and Fernando Gomez-Pinilla. “‘Metabolic Syndrome’ in the Brain: Deficiency in Omega-3 Fatty Acid Exacerbates Dysfunctions in Insulin Receptor Signalling and Cognition.” The Journal of Physiology 590.Pt 10 (2012): 2485–2499. PMC. Web. 7 Aug. 2015.

The Reality of Food Addiction: Recharged | The Paleo Diet

Cai, Dongsheng, and Tiewen Liu. “Inflammatory Cause of Metabolic Syndrome via Brain Stress and NF-κB.” Aging (Albany NY) 4.2 (2012): 98–115. Print.

It is my generation who is now having to pay for all the poor choices made by prior ones, and now more than 66% of adults are overweight or obese.65 Four years ago researchers knew that “there are a number of shared neural and hormonal pathways…that may help researchers discover why certain individuals continue to overeat despite health and other consequences”.66 And yet, some scientists refuse to even acknowledge people are addicted to food! It is maddening.

The Reality of Food Addiction: Recharged | The Paleo Diet

Sturm, Roland, and Aiko Hattori. “Morbid Obesity Rates Continue to Rise Rapidly in the US.” International journal of obesity (2005) 37.6 (2013): 889–891. PMC. Web. 7 Aug. 2015.

The results of food addiction are happening here and now.67, 68 We see them every day on the way to work, at the store, in society, and even glamorized in popular media. Certainly, no one should be ‘fat shamed’ – but we shouldn’t be celebrating obesity either. Food addiction is just as sad as drug addiction – it is just destructive over a longer period of time, rather than acutely.69, 70, 71 As science shows, the same neurobiological pathways that are implicated in drug abuse also modulate food consumption.72, 73

The Reality of Food Addiction: Recharged | The Paleo Diet

Volkow, Nora D et al. “Overlapping Neuronal Circuits in Addiction and Obesity: Evidence of Systems Pathology.” Philosophical Transactions of the Royal Society B: Biological Sciences 363.1507 (2008): 3191–3200. PMC. Web. 7 Aug. 2015.

The Reality of Food Addiction: Recharged | The Paleo Diet

Volkow, Nora D et al. “Overlapping Neuronal Circuits in Addiction and Obesity: Evidence of Systems Pathology.” Philosophical Transactions of the Royal Society B: Biological Sciences 363.1507 (2008): 3191–3200. PMC. Web. 7 Aug. 2015.

The Reality of Food Addiction: Recharged | The Paleo Diet

Baik, Ja-Hyun. “Dopamine Signaling in Food Addiction: Role of Dopamine D2 Receptors.” BMB Reports 46.11 (2013): 519–526. PMC. Web. 7 Aug. 2015.

Or how about the scientific paper which showed that Oreo cookies were as addictive as cocaine?74 Again, you will find some scientists hemming and hawing, but the reality, the way the science translates into our everyday lives, shows clear addiction. Do you feel like you need to eat the whole bag of broccoli? Obviously not. For most, vegetables are a chore. But it sure is easy to eat a whole box of Oreos! In fact, many find it hard not to.75 Does this sound addictive to you?

Then we have the case of researchers “curing binge eating” by modulating dopamine receptors.76 Why is this notable? Because by altering the brain’s response to rewarding food, we can stop the cravings/addiction! This really hammers home the point that food can be addictive, and that it is not just an innocent bystander that some people (66% of all adults, if you’re keeping track) can’t seem to stop consuming. If you wants to know more of the deep molecular mechanisms and psychology behind eating, I have also written on this very subject.

The Reality of Food Addiction: Recharged | The Paleo Diet

Green, Erin, and Claire Murphy. “Altered Processing of Sweet Taste in the Brain of Diet Soda Drinkers.” Physiology & behavior 107.4 (2012): 560–567. PMC. Web. 7 Aug. 2015.

And what is one of the most addictive, and least healthy habits in the world? Soda. The less soda you drink, the great weight loss you see.77, 78, 79 Even artificial sweeteners have shown rewarding mechanisms in the brain.80, 81, 82, 83, 84 Interestingly, new research has shown that a hormone deficiency in the brain may also be causing overeating.85, 86, 87 This is in addition to new research which shows that ‘bad’ genes may also play a role in overconsumption.88, 89, 90, 91, 92

Clearly, food addiction is a real problem, which needs to be fixed as soon as possible.93, 94 The future of (a healthy) human world…sort of depends on it. A Paleo diet is one of the best ways to go cold turkey, and stop food addiction in its tracks. By eating nutrient dense foods, sleeping soundly, and managing stress, we are taking proactive steps to avoiding food addiction and obesity.95, 96 97, 98, 99, 100

 

 

REFERENCES

[1] Avena NM, Bocarsly ME, Hoebel BG. Animal models of sugar and fat bingeing: relationship to food addiction and increased body weight. Methods Mol Biol. 2012;829:351-65.

[2] Avena NM, Rada P, Hoebel BG. Sugar bingeing in rats. Curr Protoc Neurosci. 2006;Chapter 9:Unit9.23C.

[3] Rada P, Avena NM, Hoebel BG. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience. 2005;134(3):737-44.

[4] Blum K, Thanos PK, Gold MS. Dopamine and glucose, obesity, and reward deficiency syndrome. Front Psychol. 2014;5:919.

[5] Berridge KC. ‘Liking’ and ‘wanting’ food rewards: brain substrates and roles in eating disorders. Physiol Behav. 2009;97(5):537-50.

[6] Wise RA. Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc Lond, B, Biol Sci. 2006;361(1471):1149-58.

[7] Murray S, Tulloch A, Gold MS, Avena NM. Hormonal and neural mechanisms of food reward, eating behaviour and obesity. Nat Rev Endocrinol. 2014;10(9):540-52.

[8] Blum K, Gardner E, Oscar-berman M, Gold M. “Liking” and “wanting” linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry. Curr Pharm Des. 2012;18(1):113-8.

[9] Swiecicki L, Scinska A, Bzinkowska D, et al. Intensity and pleasantness of sucrose taste in patients with winter depression. Nutr Neurosci. 2014.

[10] Kellerer M, Lammers R, Fritsche A, et al. Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance. Diabetologia. 2001;44(9):1125-32.

[11] Bellisle F, Drewnowski A. Intense sweeteners, energy intake and the control of body weight. Eur J Clin Nutr. 2007;61(6):691-700.

[12] Caffaro CE, Hirschberg CB. Nucleotide sugar transporters of the Golgi apparatus: from basic science to diseases. Acc Chem Res. 2006;39(11):805-12.

[13] Willett WC, Ludwig DS. Science souring on sugar. BMJ. 2013;346:e8077.

[14] Grant JE, Potenza MN, Weinstein A, Gorelick DA. Introduction to behavioral addictions. Am J Drug Alcohol Abuse. 2010;36(5):233-41.

[15] Greeno CG, Wing RR. Stress-induced eating. Psychol Bull. 1994;115(3):444-64.

[16] Soubry A, Murphy SK, Wang F, et al. Newborns of obese parents have altered DNA methylation patterns at imprinted genes. Int J Obes (Lond). 2013.

[17] Kerti L, Witte AV, Winkler A, Grittner U, Rujescu D, Flöel A. Higher glucose levels associated with lower memory and reduced hippocampal microstructure. Neurology. 2013;81(20):1746-52.

[18] Epstein DH, Shaham Y. Cheesecake-eating rats and the question of food addiction. Nat Neurosci. 2010;13(5):529-31.

[19] Crane PK, Walker R, Hubbard RA, et al. Glucose levels and risk of dementia. N Engl J Med. 2013;369(6):540-8.

[20] Walker RW, Dumke KA, Goran MI. Fructose content in popular beverages made with and without high-fructose corn syrup. Nutrition. 2014;30(7-8):928-35.

[21] Johnson PM, Kenny PJ. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci. 2010;13(5):635-41.

[22] Yang Q. Gain weight by “going diet?” Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. Yale J Biol Med. 2010;83(2):101-8.

[23] Popkin BM, Nielsen SJ. The sweetening of the world’s diet. Obes Res. 2003;11(11):1325-32.

[24] Brownell KD, Warner KE. The perils of ignoring history: Big Tobacco played dirty and millions died. How similar is Big Food?. Milbank Q. 2009;87(1):259-94.

[25] Sharma LL, Teret SP, Brownell KD. The food industry and self-regulation: standards to promote success and to avoid public health failures. Am J Public Health. 2010;100(2):240-6.

[26] Oliver KG, Huon GF, Zadro L, Williams KD. The role of interpersonal stress in overeating among high and low disinhibitors. Eat Behav. 2001;2(1):19-26.

[27] Copinschi G. Metabolic and endocrine effects of sleep deprivation. Essent Psychopharmacol. 2005;6(6):341-7.

[28] Harris JL, Bargh JA, Brownell KD. Priming effects of television food advertising on eating behavior. Health Psychol. 2009;28(4):404-13.

[29] Knutson KL, Spiegel K, Penev P, Van cauter E. The metabolic consequences of sleep deprivation. Sleep Med Rev. 2007;11(3):163-78.

[30] Andreyeva T, Long MW, Brownell KD. The impact of food prices on consumption: a systematic review of research on the price elasticity of demand for food. Am J Public Health. 2010;100(2):216-22.

[31] Gearhardt AN, White MA, Potenza MN. Binge eating disorder and food addiction. Curr Drug Abuse Rev. 2011;4(3):201-7.

[32] Davis C, Levitan RD, Kaplan AS, Kennedy JL, Carter JC. Food cravings, appetite, and snack-food consumption in response to a psychomotor stimulant drug: the moderating effect of “food-addiction”. Front Psychol. 2014;5:403.

[33] Dimitrijević I, Popović N, Sabljak V, Škodrić-trifunović V, Dimitrijević N. Food addiction-diagnosis and treatment. Psychiatr Danub. 2015;27(1):101-6.

[34] Schulte EM, Avena NM, Gearhardt AN. Which foods may be addictive? The roles of processing, fat content, and glycemic load. PLoS ONE. 2015;10(2):e0117959.

[35] Meule A, Hermann T, Kübler A. Food addiction in overweight and obese adolescents seeking weight-loss treatment. Eur Eat Disord Rev. 2015;23(3):193-8.

[36] Hardman CA, Rogers PJ, Dallas R, Scott J, Ruddock HK, Robinson E. “Food addiction is real”. The effects of exposure to this message on self-diagnosed food addiction and eating behaviour. Appetite. 2015;91:179-84.

[37] Schulte EM, Joyner MA, Potenza MN, Grilo CM, Gearhardt AN. Current considerations regarding food addiction. Curr Psychiatry Rep. 2015;17(4):563.

[38] Piccinni A, Marazziti D, Vanelli F, et al. Food addiction spectrum: a theoretical model from normality to eating and overeating disorders. Curr Med Chem. 2015;22(13):1631-8.

[39] Pedram P, Sun G. Hormonal and dietary characteristics in obese human subjects with and without food addiction. Nutrients. 2015;7(1):223-38.

[40] Karlsson HK, Tuominen L, Tuulari JJ, et al. Obesity is associated with decreased μ-opioid but unaltered dopamine D2 receptor availability in the brain. J Neurosci. 2015;35(9):3959-65.

[41] Hebebrand J, Albayrak Ö, Adan R, et al. “Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior. Neurosci Biobehav Rev. 2014;47:295-306.

[42] Ziauddeen H, Fletcher PC. Is food addiction a valid and useful concept?. Obes Rev. 2013;14(1):19-28.

[43] Barry D, Clarke M, Petry NM. Obesity and its relationship to addictions: is overeating a form of addictive behavior?. Am J Addict. 2009;18(6):439-51.

[44] Ogden J, Clementi C. The experience of being obese and the many consequences of stigma. J Obes. 2010;2010

[45] Fortuna JL. The obesity epidemic and food addiction: clinical similarities to drug dependence. J Psychoactive Drugs. 2012;44(1):56-63.

[46] Moreira PI. High-sugar diets, type 2 diabetes and Alzheimer’s disease. Curr Opin Clin Nutr Metab Care. 2013;16(4):440-5.

[47] Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among u.s. Adults. Diabetes Care. 2004;27(10):2444-9.

[48] Daly M. Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutr. 2003;78(4):865S-872S.

[49] Musselman LP, Fink JL, Narzinski K, et al. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis Model Mech. 2011;4(6):842-9.

[50] Lythgoe A, Roberts C, Madden AM, Rennie KL. Marketing foods to children: a comparison of nutrient content between children’s and non-children’s products. Public Health Nutr. 2013;16(12):2221-30.

[51] Gallagher EJ, Leroith D, Karnieli E. Insulin resistance in obesity as the underlying cause for the metabolic syndrome. Mt Sinai J Med. 2010;77(5):511-23.

[52] Gearhardt A, Roberts M, Ashe M. If sugar is addictive…what does it mean for the law?. J Law Med Ethics. 2013;41 Suppl 1:46-9.

[53] Johnson RK, Appel LJ, Brands M, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2009;120(11):1011-20.

[54] Lustig RH, Schmidt LA, Brindis CD. Public health: The toxic truth about sugar. Nature. 2012;482(7383):27-9.

[55] Avena NM, Rada P, Hoebel BG. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev. 2008;32(1):20-39.

[56] Myers MG, Cowley MA, Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol. 2008;70:537-56.

[57] Yates KF, Sweat V, Yau PL, Turchiano MM, Convit A. Impact of metabolic syndrome on cognition and brain: a selected review of the literature. Arterioscler Thromb Vasc Biol. 2012;32(9):2060-7.

[58] Singh RB, Gupta S, Dherange P, et al. Metabolic syndrome: a brain disease. Can J Physiol Pharmacol. 2012;90(9):1171-83.

[59] Tiehuis AM, Van der graaf Y, Mali WP, et al. Metabolic syndrome, prediabetes, and brain abnormalities on mri in patients with manifest arterial disease: the SMART-MR study. Diabetes Care. 2014;37(9):2515-21.

[60] Mauro C, De rosa V, Marelli-berg F, Solito E. Metabolic syndrome and the immunological affair with the blood-brain barrier. Front Immunol. 2014;5:677.

[61] Agrawal R, Gomez-pinilla F. ‘Metabolic syndrome’ in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol (Lond). 2012;590(Pt 10):2485-99.

[62] Cai D, Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-κB. Aging (Albany NY). 2012;4(2):98-115.

[63] Buijs RM, Kreier F. The metabolic syndrome: a brain disease?. J Neuroendocrinol. 2006;18(9):715-6.

[64] Zhu S, St-onge MP, Heshka S, Heymsfield SB. Lifestyle behaviors associated with lower risk of having the metabolic syndrome. Metab Clin Exp. 2004;53(11):1503-11.

[65] Available at: //www.niddk.nih.gov/health-information/health-statistics/Pages/overweight-obesity-statistics.aspx. Accessed July 29, 2015.

[66] Zhang Y, Von deneen KM, Tian J, Gold MS, Liu Y. Food addiction and neuroimaging. Curr Pharm Des. 2011;17(12):1149-57.

[67] Kanoski SE, Davidson TL. Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav. 2011;103(1):59-68.

[68] Sturm R, Hattori A. Morbid obesity rates continue to rise rapidly in the United States. Int J Obes (Lond). 2013;37(6):889-91.

[69] Schmidt LA. New unsweetened truths about sugar. JAMA Intern Med. 2014;174(4):525-6.

[70] Ruff JS, Suchy AK, Hugentobler SA, et al. Human-relevant levels of added sugar consumption increase female mortality and lower male fitness in mice. Nat Commun. 2013;4:2245.

[71] Blaisdell AP, Lau YL, Telminova E, et al. Food quality and motivation: a refined low-fat diet induces obesity and impairs performance on a progressive ratio schedule of instrumental lever pressing in rats. Physiol Behav. 2014;128:220-5.

[72] Blumenthal DM, Gold MS. Neurobiology of food addiction. Curr Opin Clin Nutr Metab Care. 2010;13(4):359-65.

[73] Volkow ND, Wang GJ, Fowler JS, Telang F. Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Philos Trans R Soc Lond, B, Biol Sci. 2008;363(1507):3191-200.

[74] Levy A, Salamon A, Tucci M, Limebeer CL, Parker LA, Leri F. Co-sensitivity to the incentive properties of palatable food and cocaine in rats; implications for co-morbid addictions. Addict Biol. 2013;18(5):763-73.

[75] Lenoir M, Serre F, Cantin L, Ahmed SH. Intense sweetness surpasses cocaine reward. PLoS ONE. 2007;2(8):e698.

[76] Halpern CH, Tekriwal A, Santollo J, et al. Amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves D2 receptor modulation. J Neurosci. 2013;33(17):7122-9.

[77] Chen L, Appel LJ, Loria C, et al. Reduction in consumption of sugar-sweetened beverages is associated with weight loss: the PREMIER trial. Am J Clin Nutr. 2009;89(5):1299-306.

[78] Drewnowski A, Bellisle F. Liquid calories, sugar, and body weight. Am J Clin Nutr. 2007;85(3):651-61.

[79] Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(4):1084-102.

[80] Cantley LC. Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar. BMC Biol. 2014;12:8.

[81] Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014.

[82] Anton SD, Martin CK, Han H, et al. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite. 2010;55(1):37-43.

[83] Swithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab. 2013;24(9):431-41.

[84] Direct and indirect cellular effects of aspartame on the brain. European Journal of Clinical Nutrition. 2008;62(4):451.

[85] Zhiping P. Pang et al. Endogenous Glucagon-like Peptide-1 Suppresses High-Fat Food Intake by Reducing Synaptic Drive onto Mesolimbic Dopamine Neurons. Cell Reports, July 2015.

[86] Zumoff B. Hormonal abnormalities in obesity. Acta Med Scand Suppl. 1988;723:153-60.

[87] Wren AM. Gut and hormones and obesity. Front Horm Res. 2008;36:165-81.

[88] Nadia Micali, Alison E. Field, Janet L. Treasure, David M. Evans. Are obesity risk genes associated with binge eating in adolescence? Obesity, 2015; 23 (8): 1729.

[89] Stice E, Yokum S, Zald D, Dagher A. Dopamine-based reward circuitry responsivity, genetics, and overeating. Curr Top Behav Neurosci. 2011;6:81-93.

[90] Grimm ER, Steinle NI. Genetics of eating behavior: established and emerging concepts. Nutr Rev. 2011;69(1):52-60.

[91] Barry D, Clarke M, Petry NM. Obesity and its relationship to addictions: is overeating a form of addictive behavior?. Am J Addict. 2009;18(6):439-51.

[92] Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet. 2010;26(6):266-74.

[93] Gearhardt AN, Corbin WR. The role of food addiction in clinical research. Curr Pharm Des. 2011;17(12):1140-2.

[94] Pursey KM, Stanwell P, Gearhardt AN, Collins CE, Burrows TL. The prevalence of food addiction as assessed by the Yale Food Addiction Scale: a systematic review. Nutrients. 2014;6(10):4552-90.

[95] Kasim-karakas SE, Almario RU, Cunningham W. Effects of protein versus simple sugar intake on weight loss in polycystic ovary syndrome (according to the National Institutes of Health criteria). Fertil Steril. 2009;92(1):262-70.

[96] Van itallie TB. Dietary fiber and obesity. Am J Clin Nutr. 1978;31(10 Suppl):S43-52.

[97] Kowalski LM, Bujko J. [Evaluation of biological and clinical potential of paleolithic diet]. Rocz Panstw Zakl Hig. 2012;63(1):9-15.

[98] Frassetto LA, Schloetter M, Mietus-synder M, Morris RC, Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr. 2009;63(8):947-55.

[99] Boers I, Muskiet FA, Berkelaar E, et al. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study. Lipids Health Dis. 2014;13:160.

[100] Konner M, Eaton SB. Paleolithic nutrition: twenty-five years later. Nutr Clin Pract. 2010;25(6):594-602.

Not So (Artifically) Sweet | The Paleo Diet

I have had countless clients try to replace their sugar-laden diets with ones rich with artificial sweeteners. While this may work in the short term, it definitely does not work in the long term.1 2 And, the reasons for this are countless.3,

New research shows sugars specifically activate six neurosecretory cells in the brain, which produce Dh44, a homolog of the mammalian corticotropin-releasing hormone.4, 5 Artificial sweeteners do not activate these same cells – possibly leaving the brain in a half-finished reward state – potentially leading to more calories being taken in.6, 7

Not So (Artificially) Sweet | The Paleo Diet

Yang, Qing. “Gain Weight by ‘going Diet?’ Artificial Sweeteners and the Neurobiology of Sugar Cravings: Neuroscience 2010.” The Yale Journal of Biology and Medicine 83.2 (2010): 101–108. Print.

Another issue with artificial sweeteners is they are typically much, much sweeter than sugar. Just how much sweeter are these manmade creations? Most artificial sweeteners are 200-400 times sweeter than regular table sugar!8 Many researchers argue this leaves the brain expecting a plethora of calories, and also disrupts the brain’s natural reward mechanisms.9

While followers of the Paleo diet will certainly know that artificial sweeteners have no place in a healthy lifestyle, many who are trying to change their eating habits rely on artificial sweeteners for brief time periods. Not a great idea. As the scientific literature suggests, artificial sweeteners (because they are sweet) encourage sugar craving and sugar dependence.10

Even stevia, which many will argue is a healthier alternative to most artificial sweeteners, is 100-300 times sweeter than table sugar!11 It is certainly not a good idea to be consuming something that sweet on a regular basis – whether it contains sugar or not. Furthermore, artificial sweeteners are typically packaged in foods or drinks that have a laundry list of other negative substances and artificial ingredients.12

Salient scientific studies clearly show how in repeatedly exposing ourselves to sugar, we help to train our flavor preference. In short – the more sweet we eat, the more we crave and expect it. Many studies have shown lowering fat and/or salt intake, over several weeks, leads to less craving of these elements. This is exactly how you should treat sugar and artificial sweeteners.

Not So (Artificallyy) Sweet | The Paleo Diet

Sclafani, Anthony. “Sweet Taste Signaling in the Gut.” Proceedings of the National Academy of Sciences of the United States of America 104.38 (2007): 14887–14888. PMC. Web. 7 July 2015.

On a granular level, T1R2 and T1R3 sweet taste receptors are found in taste cells in the mouth and enteroendocrine cells in the gut.13 Stimulation of the T1R2 and T1R3 receptors in the mouth by sugars and artificial sweeteners activates intracellular signaling elements, which trigger peripheral taste nerves and brain gustatory pathways. This is one way in which artificial sweeteners actually have a similar effect to sugar – which is not a good thing.

Moreover, research shows substituting sucrose-sweetened drinks for diet drinks does not reduce total energy intake – and may even result in a higher intake during the following day.14 Artificial sweeteners are not the answer.

Even back in 1986, researchers concluded that the data do not support the hypothesis that long-term artificial sweetener use either helps weight loss or prevents weight gain.15

Not So (Artifically) Sweet | The Paleo Diet

Fernstrom, John D. et al. “Mechanisms for Sweetness.” The Journal of Nutrition 142.6 (2012): 1134S–1141S. PMC. Web. 7 July 2015.

So why are artificial sweeteners still used? Well, quite simply: money and industry.

Artificial sweeteners are beneficial to the food industry for a variety of reasons. One – they are cheap, and can help make poor quality foods taste ‘better’. Two – it makes it seem like they care. They sell you the sugar-laden stuff, and then – if you are ‘health conscious’ – you can buy their artificially sweetened product instead. Either way – they win.

I may be preaching to the converted here on The Paleo Diet, but often times even the most disciplined of us slowly let little ‘cheats’ into our diet – without realizing the long term impacts these seemingly innocuous choices may be having on our bodies and brains. If we have any hope of getting out of the current obesity pandemic we currently find ourselves in, it starts with removing all the sweetness (artificial or not) from our collective diet.16, 17, 18, 19, 20, 21 Your health (and waistline) will thank you for it!

 

REFERENCES

[1] Feijó Fde M, Ballard CR, Foletto KC, et al. Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels. Appetite. 2013;60(1):203-7.

[2] Bellisle F, Drewnowski A. Intense sweeteners, energy intake and the control of body weight. Eur J Clin Nutr. 2007;61(6):691-700.

[3] Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014;514(7521):181-6.

[4] Available at: //www.endocrinologyadvisor.com/neuroendocrinology/sugar-artificial-sweeteners-satiety/article/423644/. Accessed July 5, 2015.

[5] Dus M, Lai JS, Gunapala KM, et al. Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila. Neuron. 2015;87(1):139-51.

[6] Fowler SP, Williams K, Resendez RG, Hunt KJ, Hazuda HP, Stern MP. Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity (Silver Spring). 2008;16(8):1894-900.

[7] Blundell JE, Hill AJ. Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet. 1986;1(8489):1092-3.

[8] Pandurangan M, Park J, Kim E. Aspartame downregulates 3T3-L1 differentiation. In Vitro Cell Dev Biol Anim. 2014;50(9):851-7.

[9] Fernstrom JD, Munger SD, Sclafani A, De araujo IE, Roberts A, Molinary S. Mechanisms for sweetness. J Nutr. 2012;142(6):1134S-41S.

[10] Yang Q. Gain weight by “going diet?” Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. Yale J Biol Med. 2010;83(2):101-8.

[11] Goyal SK, Samsher, Goyal RK. Stevia (Stevia rebaudiana) a bio-sweetener: a review. Int J Food Sci Nutr. 2010;61(1):1-10.

[12] Kellett GL, Brot-laroche E, Mace OJ, Leturque A. Sugar absorption in the intestine: the role of GLUT2. Annu Rev Nutr. 2008;28:35-54.

[13] Sclafani A. Sweet taste signaling in the gut. Proc Natl Acad Sci USA. 2007;104(38):14887-8.

[14] Lavin JH, French SJ, Read NW. The effect of sucrose- and aspartame-sweetened drinks on energy intake, hunger and food choice of female, moderately restrained eaters. Int J Obes Relat Metab Disord. 1997;21(1):37-42.

[15] Stellman SD, Garfinkel L. Artificial sweetener use and one-year weight change among women. Prev Med. 1986;15(2):195-202.

[16] Swinburn BA, Sacks G, Hall KD, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378(9793):804-14.

[17] Soeliman FA, Azadbakht L. Weight loss maintenance: A review on dietary related strategies. J Res Med Sci. 2014;19(3):268-75.

[18] Lustig RH. Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc. 2010;110(9):1307-21.

[19] Isganaitis E, Lustig RH. Fast food, central nervous system insulin resistance, and obesity. Arterioscler Thromb Vasc Biol. 2005;25(12):2451-62.

[20] Lustig RH, Sen S, Soberman JE, Velasquez-mieyer PA. Obesity, leptin resistance, and the effects of insulin reduction. Int J Obes Relat Metab Disord. 2004;28(10):1344-8.

[21] Lustig RH. The neuroendocrinology of obesity. Endocrinol Metab Clin North Am. 2001;30(3):765-85.

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