Tag Archives: anti-inflammatory

Anti-Inflammatory Effects of a Ketogenic Diet | The Paleo Diet

Many are aware that ketogenic diets offer a plethora of health benefits.1,2,3,4,5 Among the ketogenic diet’s best properties are its anti-inflammatory effects.6,7 However, despite the emerging popularity of the diet, the scientific community is still relatively uncertain about the exact beneficial mechanisms behind this dietary approach.8,9,10 Recently however, a new study was published which looked at the potential mechanisms underlying the specific anti-inflammatory properties of ketosis.11

Anti-Inflammatory Effects of a Ketogenic Diet | The Paleo Diet

Eitel, Julia. “Innate Immune Recognition and Inflammasome Activation in Listeria Monocytogenes Infection.” Frontiers. N.p., n.d. Web. 19 Feb. 2015.

For those unfamiliar, a ketogenic diet is one which contains very little – if any – carbohydrate.12 One classic example of this dietary approach is seen in the Inuit people.13 The Inuit are indigenous people, who live in the Arctic region.14 Alaska, Canada and Greenland all have Inuit populations.15 In one of the more famous nutrition stories of recent times, Dr. Vilhjalmur Stefansson ate nothing but meat for one year, after being inspired by living with the Inuit, and seeing their remarkably low rate of disease.16,17,18 This was despite the Inuit’s (then) controversial diet of nothing but meat, whether it came from fish or other sources. Stefansson saw no ill effects from a year of an all meat diet, with basically zero carbohydrate. He also consumed no vegetables. It is worth noting, that he also became very ill when he consumed only low fat meat, and nothing else. When he added the fattier meat back in, he immediately felt better.

The many reported benefits of the ketogenic diet include, but are not limited to: less hunger while dieting, improved cognitive function in those who are cognitively impaired, improved LDL cholesterol levels, improved weight loss, and improved levels of HDL cholesterol.19 This is in addition to the aforementioned anti-inflammatory effects. When we look to the scientific literature, we see that the anti-inflammatory nature of the diet has been studied for many years.20,21,22,23,24 The ketogenic diet has also been established as an adequate anticonvulsant therapy.25

This newly published research looks specifically at the ketone metabolite beta-hydroxybutyrate, which seems to inhibit the NLRP3 inflammasome.26 Since the NLRP3 inflammasome was previously found to have been linked to obesity and inflammation, as well as insulin resistance, inhibiting it would make mechanistic sense.27 The resultant weight loss and anti-inflammatory effects, commonly seem (at least anecdotally) when adopting a ketogenic diet, would then make sense as well. The NLRP3 inflammasome also drives the inflammatory response in several disorders including autoimmune diseases, type 2 diabetes, Alzheimer’s disease, atherosclerosis, and autoinflammatory disorders.28,29

Anti-Inflammatory Effects of a Ketogenic Diet | The Paleo Diet

Kossoff, Eric H. “More Fat and Fewer Seizures: Dietary Therapies for Epilepsy.” The Lancet. N.p., July 2014. 

Anti-Inflammatory Effects of a Ketogenic Diet | The Paleo Diet

Menu, P, and J E Vince. “The NLRP3 Inflammasome in Health and Disease: The Good, the Bad and the Ugly.” Clinical and Experimental Immunology 166.1 (2011): 1–15. PMC. Web. 19 Feb. 2015.

Could it all be so simple? Possibly, though there is certainly likely more to be more scientific discoveries, relating to the beneficial effects of this specific dietary approach. Moving away from glucose and instead utilizing ketone bodies as a source of metabolic fuel, results in many profound changes, of which we are only beginning to scratch the surface of, scientifically.30,31,32

This new discovery will likely be the first of many new findings regarding the ketogenic diet, and its abundance of benefits. If you are looking to adopt a ketogenic approach, simply follow the many nutritious tenets of the Paleo Diet, and then lower your carbohydrate intake to below 100g per day. How low you need to go for optimum quality of life is highly variant, and many people report different results with different amounts of carbohydrates. Dialing in the best nutrition plan for you, when adopting a ketogenic diet, is integral. Be sure to consult with a professional to avoid possible nutrient deficiencies.

 

REFERENCES

[1] Dashti HM, Mathew TC, Hussein T, et al. Long-term effects of a ketogenic diet in obese patients. Exp Clin Cardiol. 2004;9(3):200-5.

[2] Paoli A. Ketogenic diet for obesity: friend or foe?. Int J Environ Res Public Health. 2014;11(2):2092-107.

[3] Zajac A, Poprzecki S, Maszczyk A, Czuba M, Michalczyk M, Zydek G. The effects of a ketogenic diet on exercise metabolism and physical performance in off-road cyclists. Nutrients. 2014;6(7):2493-508.

[4] Hussain TA, Mathew TC, Dashti AA, Asfar S, Al-zaid N, Dashti HM. Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes. Nutrition. 2012;28(10):1016-21.

[5] Millichap JG, Yee MM. The diet factor in attention-deficit/hyperactivity disorder. Pediatrics. 2012;129(2):330-7.

[6] Schugar RC, Crawford PA. Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care. 2012;15(4):374-80.

[7] Masino SA, Kawamura M, Wasser CD, Wasser CA, Pomeroy LT, Ruskin DN. Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr Neuropharmacol. 2009;7(3):257-68.

[8] Poff AM, Ari C, Seyfried TN, D’agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS ONE. 2013;8(6):e65522.

[9] Krilanovich NJ. Benefits of ketogenic diets. Am J Clin Nutr. 2007;85(1):238-9.

[10] Mandel A, Ballew M, Pina-Garza JE, Stalmasek V, Clemens LH. Medical costs are reduced when children with intractable epilepsy are successfully treated with the ketogenic diet. J Am Diet Assoc 2002;102:396–8.

[11] Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;

[12] Rogovik AL, Goldman RD. Ketogenic diet for treatment of epilepsy. Can Fam Physician. 2010;56(6):540-2.

[13] Phinney SD. Ketogenic diets and physical performance. Nutr Metab (Lond). 2004;1(1):2.

[14] Bjerregaard P, Dewailly E, Young TK, et al. Blood pressure among the Inuit (Eskimo) populations in the Arctic. Scand J Public Health. 2003;31(2):92-9.

[15] Helgason A, Pálsson G, Pedersen HS, et al. mtDNA variation in Inuit populations of Greenland and Canada: migration history and population structure. Am J Phys Anthropol. 2006;130(1):123-34.

[16] Stefansson V: Not by bread alone. The MacMillan Co, NY 1946. Introductions by Eugene F. DuBois, MD, pp ix-xiii; and Earnest Hooton PhD, ScD, pp xv-xvi.

[17] McClellan WS, DuBois EF: Clinical calorimetry XLV: Prolonged meat diets with a study of kidney function and ketosis. J Biol Chem 1930, 87:651-68.

[18] McClellan WS, Rupp VR, Toscani V: Clinical calorimetry XLVI: prolonged meat diets with a study of the metabolism of nitrogen, calcium, and phosphorus. J Biol Chem 1930, 87:669-80.

[19] Pérez-guisado J. [Ketogenic diets: additional benefits to the weight loss and unfounded secondary effects]. Arch Latinoam Nutr. 2008;58(4):323-9.

[20] Yang X, Cheng B. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. J Mol Neurosci. 2010;42(2):145-53.

[21] Masino SA, Kawamura M, Wasser CD, Wasser CA, Pomeroy LT, Ruskin DN. Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr Neuropharmacol. 2009;7(3):257-68.

[22] Gasior M, Rogawski MA, Hartman AL. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol. 2006;17(5-6):431-9.

[23] Kim do Y, Hao J, Liu R, Turner G, Shi FD, Rho JM. Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS ONE. 2012;7(5):e35476.

[24] Masino SA, Ruskin DN. Ketogenic diets and pain. J Child Neurol. 2013;28(8):993-1001.

[25] Bough KJ, Rho JM. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia. 2007;48(1):43-58.

[26] Youm YH, Nguyen KY, Grant RW, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;

[27] Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011;17(2):179-88.

[28] Menu P, Vince JE. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol. 2011;166(1):1-15.

[29] Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469(7329):221-5.

[30] Guzmán M, Blázquez C. Ketone body synthesis in the brain: possible neuroprotective effects. Prostaglandins Leukot Essent Fatty Acids. 2004;70(3):287-92.

[31] Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev. 1999;15(6):412-26.

[32] Henderson ST. Ketone bodies as a therapeutic for Alzheimer’s disease. Neurotherapeutics. 2008;5(3):470-80.

Almond Lime Kale Salad

During the past several years, kale has become a favorite “superfood” vegetable around the world. Despite its meteoric rise to prominence, kale has always been a favorite food of farmers because it grows fast, resists frost, and requires very little fertilizer.1 Kale is a winter vegetable, so now is a great time to start including it in your meals.

Nutritionally speaking, kale is a rock star, boasting high amounts of beta-carotene, vitamin C, and vitamin K. It’s also a rich source of phytonutrients, including the flavonoid kaempferol. Epidemiological studies associate kaempferol consumption with reduced rates of several degenerative diseases and numerous preclinical studies have shown kaempferol to have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, and neuroprotective.2

In this recipe, we’re pairing kale with almonds. Like all seeds, almonds contain phytic acid, a chelating “antinutrient” with a propensity for binding with calcium, magnesium, iron, and zinc, thereby inhibiting the absorption of these critical minerals.3 You can reduce the phytic acid by soaking the almonds in water for at least eight hours or, preferably, 24. From a culinary perspective, this also improves the taste and texture of the almonds.

Helpful hint: Soak one or two cups of almonds, then discard the soaking water, pat-dry the almonds with a kitchen towel, and store them in your refrigerator for 5 – 7 days. Not only will you always have some handy for a recipe, but also for a quick, nutritious snack.

INGREDIENTS

Serves 1

  • 3 – 4 kale leaves
  • 1 tbsp coconut oil
  • 1 clove garlic, pressed
  • ½-inch piece of ginger, finely chopped
  • ½ cup almonds, soaked at least 8 hours
  • ½ lime, juiced
  • 2 tbsp olive oil

DIRECTIONS

kale-and-almonds4
Remove and discard the stems from the kale leaves. Chop leaves into bite-sized pieces.
4 item(s) « 1 of 4 »
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Christopher James Clark, B.B.A.
@nutrigrail
Nutritional Grail
www.ChristopherJamesClark.com

Christopher James Clark | The Paleo Diet TeamChristopher James Clark, B.B.A. is an award-winning writer, consultant, and chef with specialized knowledge in nutritional science and healing cuisine. He has a Business Administration degree from the University of Michigan and formerly worked as a revenue management analyst for a Fortune 100 company. For the past decade-plus, he has been designing menus, recipes, and food concepts for restaurants and spas, coaching private clients, teaching cooking workshops worldwide, and managing the kitchen for a renowned Greek yoga resort. Clark is the author of the critically acclaimed, award-winning book, Nutritional Grail.

See more recipes!

 

references

1. Straight, K. (July 20, 2014). Rub of the Greens. ABC News. Retrieved from //www.abc.net.au/landline/content/2014/s4049600.htm

2. Calderón-Montaño, JM, et al. (April 2011). A review on the dietary flavonoid kaempferol. Mini Reviews in Medical Chemistry, 11(4). Retrieved from //www.ncbi.nlm.nih.gov/pubmed/21428901

3. Torre, M, et al. (1991). Effects of dietary fiber and phytic acid on mineral availability. Critical Reviews in Food Science and Nutrition, 30(1). Retrieved from //www.ncbi.nlm.nih.gov/pubmed/1657026

4 Anti-inflammatory Farmers Market Finds

National Farmer’s Market week celebrates two distinct and important aspects of this way of eating: locally-sourced foods and seasonally appropriate. And to that end, here are a few great, nutrient-dense seasonal foods you may find at your local market to include in your Paleo menu. Many of them provide not only a great variety of flavors, but also anti-inflammatory, anti-carcinogenic, and otherwise health-promoting compounds. 2, 6

Broccoli

Broccoli is rich in vitamin C and fibre, and is surprisingly high in protein. It is a source of some potent phytochemicals, such as sulforaphane and indole-3-carbinol, which have demonstrated protective effects in models of cancer, neurodegenerative diseases, and other conditions.1, 5, 11 Sautéed with a little garlic (another nutritional powerhouse) in olive oil, and you’ve got a delicious side dish for any Paleo meal.

Tomatoes

Tomatoes are a good source of antioxidants, retinoids (vitamin A-like compounds), and lycopene. The latter has been shown to protect the skin from the damaging effects of excess ultraviolet radiation – which might come in handy in the summer months, coincidentally, when tomatoes are in season.4, 7, 10 Cooking tomatoes maximizes the lycopene content,3 perfect for a summer Paleo Gazpacho.

If you have an autoimmune disease, certain glycoalkaloids in tomatoes may act to increase intestinal permeability and also contain certain immunological adjuvants (alpha tomatine in tomatoes) that up-regulate the immune response and should be avoided.

Zucchini

Zucchini is rich in folate, copper, and potassium, and is an extremely low-calorie food; only about 10-15 calories in a whole zucchini. It’s also one of the best sources for lutein and zeaxanthin, two phytonutrients that are good for ocular health.9 Zucchini has a delicate flavor which has been described as savory by some, and can be sliced, grilled, and ready-to-eat in just a few minutes.

Raspberries

Raspberries are another great source of antioxidants and anthocyanins. One study showed the equivalent of about a handful of raspberries per day reduces markers of inflammation in the blood while another study showed potentially protective effects against colorectal cancer. 8

While this is a terribly abbreviated list, you’ll surely find many other great Paleo Diet approved options at your local Farmer’s Market, so by all means, enjoy!

William Lagakos, Ph.D.
@caloriesproper
CaloriesProper

William Lagakos, Ph.D.Dr. William Lagakos received a Ph.D. in Nutritional Biochemistry and Physiology from Rutgers University where his research focused on dietary fat assimilation and integrated energy metabolism. His postdoctoral research at the University of California, San Diego, centered on obesity, inflammation, and insulin resistance. Dr. William Lagakos has authored numerous manuscripts which have been published in peer-reviewed journals, as well as a non-fiction book titled The Poor, Misunderstood Calorie which explores the concept of calories and simultaneously explains how hormones and the neuroendocrine response to foods regulate nutrient partitioning. He is presently a nutritional sciences researcher, consultant, and blogger.

References

1. Jayakumar P, Pugalendi KV, Sankaran M. Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3′- diindolylmethane in C57BL/6J mice. J Physiol Biochem. Jun 2014;70(2):525-534.

2. Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, . . . Yang G. Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women. J Acad Nutr Diet. May 2014;114(5):700-708 e702.

3. Kamiloglu S, Demirci M, Selen S, Toydemir G, Boyacioglu D, Capanoglu E. Home processing of tomatoes (Solanum lycopersicum): effects on in vitro bioaccessibility of total lycopene, phenolics, flavonoids, and antioxidant capacity. J Sci Food Agric. Aug 2014;94(11):2225-2233.

4. Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Exp Biol Med (Maywood). Nov 2002;227(10):845-851.

5. Lenzi M, Fimognari C, Hrelia P. Sulforaphane as a promising molecule for fighting cancer. Cancer Treat Res. 2014;159:207-223.

6. Macready AL, George TW, Chong MF, Alimbetov DS, Jin Y, Vidal A, . . . Group FS. Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease–FLAVURS: a randomized controlled trial. Am J Clin Nutr. Mar 2014;99(3):479-489.

7. Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin MA, Watson RE, Rhodes LE. Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. Br J Dermatol. Jan 2011;164(1):154-162.

8. Sardo CL, Kitzmiller JP, Apseloff G, Harris RB, Roe DJD, Stoner GD, Jacobs ET. An Open-Label Randomized Crossover Trial of Lyophilized Black Raspberries on Postprandial Inflammation in Older Overweight Males: A Pilot Study. Am J Ther. Aug 26 2013.

9. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol. Aug 1998;82(8):907-910.

10. Stahl W, Heinrich U, Aust O, Tronnier H, Sies H. Lycopene-rich products and dietary photoprotection. Photochem Photobiol Sci. Feb 2006;5(2):238-242.

11. Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P. Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell Longev. 2013;2013:415078.

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