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The latest from The Paleo Diet®, just for you.

Hot topics, new recipes, and science

Seminal Research

The Paleo Diet® is different from other diets in that it grew out of an unbiased review of the existing research. Dr. Cordain, one of the founders of the diet and a professor at Colorado State University, was also a runner who at first just wanted to improve his diet to help his performance. After a decade of reading the research and collaborating with people like Dr. Boyd Eaton, The Paleo Diet was the result. This section contains some of the seminal peer-reviewed publications that grew out of that research.

O’Keefe JH, Bergman N, Carrera-Bastos P, Fontes-Villalba M, DiNicolantonio JJ, Cordain L. Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa. Open Heart. 2016 Mar 22;3(1):e000325. doi: 10.1136/openhrt-2015-000325. http://www.ncbi.nlm.nih.gov/pu...

Melnik BC, Kakulas F, Geddes DT, Hartmann PE, John SW, Carrer-Bastos P, Cordain L, Schmitz G. Milk miRNAs: simple nutrients or systemic functional regulators? Nutr Metabol 13:42, DOI 10.1186/s12986-016-0101-2 https://nutritionandmetabolism...

Paleolithic Nutrition for Metabolic Syndrome: Systematic Review and Meta-analysis http://ajcn.nutrition.org/cont...

The Microbiome of Uncontacted Amerindians http://advances.sciencemag.org...

Metabolic and Physiologic Effects from Consuming a Hunter-Gatherer (Paleolithic) Diet in Type 2 Diabetes http://www.nature.com/ejcn/jou...

Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity http://www.mdpi.com/2072-6643/...

Plant-rich Mixed Meals Based on Palaeolithic Diet Principles Have Dramatic Impact on Incretin, Peptide YY and Satiety Response, but Show Little Effect on Glucose and Insulin Homeostasis https://www.cambridge.org/core...

Favourable Effects of Consuming a Palaeolithic-Type Diet on Characteristics of the Metabolic Syndrome http://www.lipidworld.com/cont...

Impact of a Paleolithic Diet on Modifiable Cardiovascular Risk Factors http://www.lipidjournal.com/ar...

Unrestricted Paleolithic Diet is Associated with Unfavorable Changes to Blood Lipids in Healthy Subjects http://digitalcommons.wku.edu/...

Long-Term Effects of a Palaeolithic-Type Diet in Obese Postmenopausal Women: A 2-Year Randomized Trial. http://www.nature.com/ejcn/jou...

A Multimodal Intervention for Patients with Secondary Progressive Multiple Sclerosis: Feasibility and Effect on Fatigue http://online.liebertpub.com/d...

A Healthy Diet With and Without Cereal Grains and Dairy Products in Patients with Type 2 Diabetes http://www.trialsjournal.com/c...

Estimates of Net Acid Production Do Not Predict Measured Net Acid Excretion inType 2 Diabetes Patients on Paleolithic Diets http://www.nature.com/ejcn/jou...

A Palaeolithic-Type Diet Causes Strong Tissue-Specific Effects on Ectopic Fat Deposition in Obese Postmenopausal Women http://onlinelibrary.wiley.com...

Subjective Satiety and Other Experiences of a Paleolithic Diet Compared to a Diabetes Diet in Patients with Type 2 Diabetes http://www.nutritionj.com/cont...

A Mediterranean Diet Improves HbA1c But Not Fasting Blood Glucose Compared to Alternative Dietary Strategies: A Network Meta-Analysis https://onlinelibrary.wiley.co...

A Paleolithic Diet is More Satiating Per Calorie Than a Mediterranean-Like Diet in Individuals with Ischemic Heart Disease http://www.nutritionandmetabol...

Metabolic and Physiologic Improvements from Consuming a Paleolithic, Hunter-Gatherer Type Diet http://www.nature.com/ejcn/jou...

Beneficial Effects of a Paleolithic Diet on Cardiovascular Risk Factors in Type 2 Diabetes: A Randomized Cross-Over Pilot Study http://www.cardiab.com/content...

Effects of a Short-Term Intervention with a Paleolithic Diet in Healthy Volunteers http://www.nature.com/ejcn/jou...

A Palaeolithic Diet Improves Glucose Tolerance More Than a Mediterranean-Like Diet in Individuals with Ischaemic Heart Disease http://link.springer.com/artic...

Paleolithic Diet Confers Higher Insulin Sensitivity, Lower C-Reactive Protein and Lower Blood Pressure Than a Cereal-Based Diet http://www.nutritionandmetabol...

Improvement in Carb and Lipid Metabolism in Diabetic Australian Aborigines After Temporary Reversion to Traditional Lifestyle http://diabetes.diabetesjourna...

Paleolithic and Mediterranean Diet Pattern Scores and Risk of Incident, Sporadic Colorectal Adenomas http://aje.oxfordjournals.org/...

Diet-induced Weight Loss has Chronic Tissue-specific Effects on Glucocorticoid Metabolism http://www.nature.com/ijo/jour...

Metabolic Effects of Milk Protein Intake Strongly Depend on Pre-existing Metabolic and Exercise Status http://www.nutritionandmetabol...

African Hominin Stable Isotopic Data Do Not Necessarily Indicate Grass Consumption https://www.pnas.org/content/1...

Impact of Cow’s Milk-mediated mTORC1-signaling in the Initiation and Progression of Prostate Cancer http://www.nutritionandmetabol...

The Western Diet and Lifestyle and Diseases of Civilization https://www.dovepress.com/the-...

Organic Physical Fitness Prescription: Exercise Like a Hunter Gatherer https://www.sciencedirect.com/...

Malaria and Rickets Represent Selective Forces for the Convergent Evolution of Adult Lactase Persistence https://www.researchgate.net/p...

Diet Dependent Acid Load, Paleolithic Nutrition, and Evolutionary Health Promotion http://ajcn.nutrition.org/cont...

Genomes and Fatty Acid Intake from East African Paleolithic Diet https://thepaleodiet.com/wp-co...

Organic Fitness Consistent with Our Hunter Gatherer Heritage https://thepaleodiet.com/wp-co...

Paleolithic Athlete: The Original Cross Trainer https://thepaleodiet.com/wp-co...

Evolution, Body Composition, Insulin Receptor Competition, and Insulin Resistance https://thepaleodiet.com/wp-co...

Dietary Fat Quality and Coronary Heart Disease Prevention https://thepaleodiet.com/wp-co...

Paleolithic Nutrition: What Did Our Ancestors Eat? http://www.scienceschool.usyd....

Actividad Fisica, Gasto Energetico y Forma Física http://g-se.com/es/salud-y-fit...

Comment on Acne and Glycemic Index http://www.jaad.org/article/S0...

The Ancestral Biomedical Environment https://thepaleodiet.com/wp-co...

Coronary Artery Disease Prognosis and C Reactive Protein-Levels Improve in Proportion to Percent Lowering of Low Density Lipoprotein https://thepaleodiet.com/wp-co...

Ultraviolet Radiation Represents an Evolutionary Selective Pressure for the South-to-North Gradient of the MTHFR 677TT Genotype http://ajcn.nutrition.org/cont...

Saturated Fat Consumption in Ancestral Human Diets https://thepaleodiet.com/wp-co...

Implications of Plio-Pleistocene Hominin Diets for Modern Humans https://thepaleodiet.com/wp-co...

Dietary Implications for the Development of Acne: A Shifting Paradigm https://thepaleodiet.com/wp-co...

Optimal Lipids, Statins, and Dementia https://thepaleodiet.com/wp-co...

Origins and Evolution of the Western Diet: Health Implications for the 21st Century http://ajcn.nutrition.org/cont...

Dissociation of the Glycaemic and Insulinaemic Responses to Whole Milk https://thepaleodiet.com/wp-co...

Implications for the Role of Diet in Acne https://s3.amazonaws.com/paleo...

Realigning Our 21st Century Diet and Lifestyle with Our Hunter-Gatherer Genetic Identity http://www.direct-ms.org/pdf/E...

Response: Optimal Low-Density Lipoprotein (LDL) https://thepaleodiet.com/wp-co...

Cardiovascular Disease Resulting From a Diet and Lifestyle at Odds With Our Paleolithic Genome http://www.mayoclinicproceedin...

The Hunter-Gatherer Diet http://www.mayoclinicproceedin...

Serum Uric Acid in Traditional Pacific Islanders and in Swedes http://onlinelibrary.wiley.com...

Optimal Low-Density Lipoprotein https://thepaleodiet.com/wp-co...

Hyperinsulinemic Diseases of Civilization: More Than Just Syndrome X https://thepaleodiet.com/wp-co...

Determinants of Serum Triglycerides and High-Density Lipoprotein Cholesterol in Traditional Trobriand Islanders https://thepaleodiet.com/wp-co...

Omega-3 Fatty Acids and Acne https://thepaleodiet.com/wp-co...

Biological and Clinical Potential of a Palaeolithic Diet https://thepaleodiet.com/wp-co...

Nutritional Characteristics of a Contemporary Diet Based Upon Paleolithic Food Groups https://thepaleodiet.com/wp-co...

Human Diet: Its Origins and Evolution https://thepaleodiet.com/wp-co...

Acne Vulgaris: A Disease of Western Civilization http://archderm.jamanetwork.co...

An Evolutionary Analysis of the Aetiology and Pathogenesis of Juvenile-onset Myopia http://onlinelibrary.wiley.com...

The Paradoxical Nature of Hunter-Gatherer Diets: Meat Based, Yet Non-Atherogenic http://www.nature.com/ejcn/jou...

Fatty Acid Analysis of Wild Ruminant Tissues: Evolutionary Implications for Reducing Diet Related Chronic Disease http://www.nature.com/ejcn/jou...

Evolutionary Health Promotion: A Consideration of Common Counter Arguments https://thepaleodiet.com/wp-co...

Evolutionary Health Promotion https://thepaleodiet.com/wp-co...

Dietary Chloride as a Possible Determinant of the Severity of Exercise Induced Asthma https://thepaleodiet.com/wp-co...

Elevating Dietary Salt Exacerbate Hyperpnea Induced Airway Obstruction http://jap.physiology.org/cont...

An Evolutionary Foundation for Health Promotion https://thepaleodiet.com/wp-co...

Fatty Acid Composition and Energy Density of Foods Available to African Hominids https://thepaleodiet.com/wp-co...

Syndrome X: Just the Tip of the Hyperinsulemia Iceberg http://www.direct-ms.org/pdf/E...

Reply to ARP Walker http://ajcn.nutrition.org/cont...

Plant-Animal Subsistence Ratios and Macronutrient Energy Estimations http://ajcn.nutrition.org/cont...

Hunter-Gatherer Diets: A Shore-Based Perspective http://ajcn.nutrition.org/cont...

Dietary Salt Alters Pulmonary Function During Exercise in Exercise Induced Asthmatics https://thepaleodiet.com/wp-co...

The Potential Role of Biotin Insufficiency on Essential Fatty Acid Metabolism and Cardiovascular Disease Risk https://thepaleodiet.com/wp-co...

A Low Sodium Diet Improves Indices Of Pulmonary Function In Exercise-Induced Asthma https://thepaleodiet.com/wp-co...

Modulation of Immune Function by Dietary Lectins | Rheumatoid Arthritis http://journals.cambridge.org/...

Plant-Animal Subsistence Ratios and Macronutrient Energy Estimations http://ajcn.nutrition.org/cont...

Scant Evidence of Periodic Starvation Among Hunter-Gatherers http://research.springer.com/s...

Cereal Grains: Humanity’s Double-Edged Sword http://www.direct-ms.org/pdf/E...

Does Creatine Supplementation Enhance Athletic Performance? https://thepaleodiet.com/wp-co...

Dietary Intake of Long-Chain Polyunsaturated Fatty Acids During the Paleolithic http://www.direct-ms.org/pdf/E...

Atherogenic Potential of Peanut Oil Based Monounsaturated Fatty Acids Diet https://thepaleodiet.com/wp-co...

Physical Activity, Energy Expenditure and Fitness: An Evolutionary Perspective https://thepaleodiet.com/wp-co...

Evolutionary Aspects of Exercise Vol I https://thepaleodiet.com/wp-co...

Evolutionary Aspects of Diet: Old Genes, New Fuels Vol II https://thepaleodiet.com/wp-co...

Achieving Hunter-gatherer Fitness in the 21(st) Century http://www.amjmed.com/article/...

Eaton SB, Cordain L, Sebastian A. The Ancestral Biomedical Environment In: Endothelial Biomedicine. W.C. Aird (Ed), Cambridge University Press, 2007, pp. 129-134. https://thepaleodiet.com/eaton...

O’Keefe JH Jr, Cordain L, Jones PG, Abuissa H. Coronary artery disease prognosis and C-reactive protein levels improve in proportion to percent lowering of low-density lipoprotein. Am J Cardiol. 2006 Jul 1;98(1):135-9. https://thepaleodiet.com/okeef...

Eaton SB, Eaton SB, Cordain L, Sinclair A, Mann N. Dietary intake of long chain polyunsaturated fatty acids during the Paleolithic. World Rev Nutr Diet 1998; 83:12-23. https://thepaleodiet.com/eaton...

Paleo Leadership
 
Trevor Connor
Trevor Connor

Dr. Loren Cordain’s final graduate student, Trevor Connor, M.S., brings more than a decade of nutrition and physiology expertise to spearhead the new Paleo Diet team.

Mark J Smith
Dr. Mark Smith

One of the original members of the Paleo movement, Mark J. Smith, Ph.D., has spent nearly 30 years advocating for the benefits of Paleo nutrition.

Nell Stephenson
Nell Stephenson

Ironman athlete, mom, author, and nutrition blogger Nell Stephenson has been an influential member of the Paleo movement for over a decade.

Loren Cordain
Dr. Loren Cordain

As a professor at Colorado State University, Dr. Loren Cordain developed The Paleo Diet® through decades of research and collaboration with fellow scientists around the world.