The Paleo Diet® | Seminal Research
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Seminal Research

The Paleo Diet® is different from other diets in that it grew out of an unbiased review of the existing research. Dr. Cordain, one of the founders of the diet and a professor at Colorado State University, was also a runner who at first just wanted to improve his diet to help his performance. After a decade of reading the research and collaborating with people like Dr. Boyd Eaton, The Paleo Diet was the result. This section contains some of the seminal peer-reviewed publications that grew out of that research.

O’Keefe JH, Bergman N, Carrera-Bastos P, Fontes-Villalba M, DiNicolantonio JJ, Cordain L. Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa. Open Heart. 2016 Mar 22;3(1):e000325. doi: 10.1136/openhrt-2015-000325.

Melnik BC, Kakulas F, Geddes DT, Hartmann PE, John SW, Carrer-Bastos P, Cordain L, Schmitz G. Milk miRNAs: simple nutrients or systemic functional regulators? Nutr Metabol 13:42, DOI 10.1186/s12986-016-0101-2 https://nutritionandmetabolism...

Paleolithic Nutrition for Metabolic Syndrome: Systematic Review and Meta-analysis

The Microbiome of Uncontacted Amerindians

Metabolic and Physiologic Effects from Consuming a Hunter-Gatherer (Paleolithic) Diet in Type 2 Diabetes

Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity

Plant-rich Mixed Meals Based on Palaeolithic Diet Principles Have Dramatic Impact on Incretin, Peptide YY and Satiety Response, but Show Little Effect on Glucose and Insulin Homeostasis

Favourable Effects of Consuming a Palaeolithic-Type Diet on Characteristics of the Metabolic Syndrome

Impact of a Paleolithic Diet on Modifiable Cardiovascular Risk Factors

Unrestricted Paleolithic Diet is Associated with Unfavorable Changes to Blood Lipids in Healthy Subjects

Long-Term Effects of a Palaeolithic-Type Diet in Obese Postmenopausal Women: A 2-Year Randomized Trial.

A Multimodal Intervention for Patients with Secondary Progressive Multiple Sclerosis: Feasibility and Effect on Fatigue

A Healthy Diet With and Without Cereal Grains and Dairy Products in Patients with Type 2 Diabetes

Estimates of Net Acid Production Do Not Predict Measured Net Acid Excretion inType 2 Diabetes Patients on Paleolithic Diets

A Palaeolithic-Type Diet Causes Strong Tissue-Specific Effects on Ectopic Fat Deposition in Obese Postmenopausal Women

Subjective Satiety and Other Experiences of a Paleolithic Diet Compared to a Diabetes Diet in Patients with Type 2 Diabetes

A Mediterranean Diet Improves HbA1c But Not Fasting Blood Glucose Compared to Alternative Dietary Strategies: A Network Meta-Analysis

A Paleolithic Diet is More Satiating Per Calorie Than a Mediterranean-Like Diet in Individuals with Ischemic Heart Disease http://www.nutritionandmetabol...

Metabolic and Physiologic Improvements from Consuming a Paleolithic, Hunter-Gatherer Type Diet

Beneficial Effects of a Paleolithic Diet on Cardiovascular Risk Factors in Type 2 Diabetes: A Randomized Cross-Over Pilot Study

Effects of a Short-Term Intervention with a Paleolithic Diet in Healthy Volunteers

A Palaeolithic Diet Improves Glucose Tolerance More Than a Mediterranean-Like Diet in Individuals with Ischaemic Heart Disease

Paleolithic Diet Confers Higher Insulin Sensitivity, Lower C-Reactive Protein and Lower Blood Pressure Than a Cereal-Based Diet http://www.nutritionandmetabol...

Improvement in Carb and Lipid Metabolism in Diabetic Australian Aborigines After Temporary Reversion to Traditional Lifestyle http://diabetes.diabetesjourna...

Paleolithic and Mediterranean Diet Pattern Scores and Risk of Incident, Sporadic Colorectal Adenomas

Diet-induced Weight Loss has Chronic Tissue-specific Effects on Glucocorticoid Metabolism

Metabolic Effects of Milk Protein Intake Strongly Depend on Pre-existing Metabolic and Exercise Status http://www.nutritionandmetabol...

African Hominin Stable Isotopic Data Do Not Necessarily Indicate Grass Consumption

Impact of Cow’s Milk-mediated mTORC1-signaling in the Initiation and Progression of Prostate Cancer http://www.nutritionandmetabol...

The Western Diet and Lifestyle and Diseases of Civilization

Organic Physical Fitness Prescription: Exercise Like a Hunter Gatherer

Malaria and Rickets Represent Selective Forces for the Convergent Evolution of Adult Lactase Persistence

Diet Dependent Acid Load, Paleolithic Nutrition, and Evolutionary Health Promotion

Genomes and Fatty Acid Intake from East African Paleolithic Diet

Organic Fitness Consistent with Our Hunter Gatherer Heritage

Paleolithic Athlete: The Original Cross Trainer

Evolution, Body Composition, Insulin Receptor Competition, and Insulin Resistance

Dietary Fat Quality and Coronary Heart Disease Prevention

Paleolithic Nutrition: What Did Our Ancestors Eat? http://www.scienceschool.usyd....

Actividad Fisica, Gasto Energetico y Forma Física

Comment on Acne and Glycemic Index

The Ancestral Biomedical Environment

Coronary Artery Disease Prognosis and C Reactive Protein-Levels Improve in Proportion to Percent Lowering of Low Density Lipoprotein

Ultraviolet Radiation Represents an Evolutionary Selective Pressure for the South-to-North Gradient of the MTHFR 677TT Genotype

Saturated Fat Consumption in Ancestral Human Diets

Implications of Plio-Pleistocene Hominin Diets for Modern Humans

Dietary Implications for the Development of Acne: A Shifting Paradigm

Optimal Lipids, Statins, and Dementia

Origins and Evolution of the Western Diet: Health Implications for the 21st Century

Dissociation of the Glycaemic and Insulinaemic Responses to Whole Milk

Implications for the Role of Diet in Acne

Realigning Our 21st Century Diet and Lifestyle with Our Hunter-Gatherer Genetic Identity

Response: Optimal Low-Density Lipoprotein (LDL)

Cardiovascular Disease Resulting From a Diet and Lifestyle at Odds With Our Paleolithic Genome http://www.mayoclinicproceedin...

The Hunter-Gatherer Diet http://www.mayoclinicproceedin...

Serum Uric Acid in Traditional Pacific Islanders and in Swedes

Optimal Low-Density Lipoprotein

Hyperinsulinemic Diseases of Civilization: More Than Just Syndrome X

Determinants of Serum Triglycerides and High-Density Lipoprotein Cholesterol in Traditional Trobriand Islanders

Omega-3 Fatty Acids and Acne

Biological and Clinical Potential of a Palaeolithic Diet

Nutritional Characteristics of a Contemporary Diet Based Upon Paleolithic Food Groups

Human Diet: Its Origins and Evolution

Acne Vulgaris: A Disease of Western Civilization

An Evolutionary Analysis of the Aetiology and Pathogenesis of Juvenile-onset Myopia

The Paradoxical Nature of Hunter-Gatherer Diets: Meat Based, Yet Non-Atherogenic

Fatty Acid Analysis of Wild Ruminant Tissues: Evolutionary Implications for Reducing Diet Related Chronic Disease

Evolutionary Health Promotion: A Consideration of Common Counter Arguments

Evolutionary Health Promotion

Dietary Chloride as a Possible Determinant of the Severity of Exercise Induced Asthma

Elevating Dietary Salt Exacerbate Hyperpnea Induced Airway Obstruction

An Evolutionary Foundation for Health Promotion

Fatty Acid Composition and Energy Density of Foods Available to African Hominids

Syndrome X: Just the Tip of the Hyperinsulemia Iceberg

Reply to ARP Walker

Plant-Animal Subsistence Ratios and Macronutrient Energy Estimations

Hunter-Gatherer Diets: A Shore-Based Perspective

Dietary Salt Alters Pulmonary Function During Exercise in Exercise Induced Asthmatics

The Potential Role of Biotin Insufficiency on Essential Fatty Acid Metabolism and Cardiovascular Disease Risk

A Low Sodium Diet Improves Indices Of Pulmonary Function In Exercise-Induced Asthma

Modulation of Immune Function by Dietary Lectins | Rheumatoid Arthritis

Plant-Animal Subsistence Ratios and Macronutrient Energy Estimations

Scant Evidence of Periodic Starvation Among Hunter-Gatherers

Cereal Grains: Humanity’s Double-Edged Sword

Does Creatine Supplementation Enhance Athletic Performance?

Dietary Intake of Long-Chain Polyunsaturated Fatty Acids During the Paleolithic

Atherogenic Potential of Peanut Oil Based Monounsaturated Fatty Acids Diet

Physical Activity, Energy Expenditure and Fitness: An Evolutionary Perspective

Evolutionary Aspects of Exercise Vol I

Evolutionary Aspects of Diet: Old Genes, New Fuels Vol II

Achieving Hunter-gatherer Fitness in the 21(st) Century

Eaton SB, Cordain L, Sebastian A. The Ancestral Biomedical Environment In: Endothelial Biomedicine. W.C. Aird (Ed), Cambridge University Press, 2007, pp. 129-134.

O’Keefe JH Jr, Cordain L, Jones PG, Abuissa H. Coronary artery disease prognosis and C-reactive protein levels improve in proportion to percent lowering of low-density lipoprotein. Am J Cardiol. 2006 Jul 1;98(1):135-9.

Eaton SB, Eaton SB, Cordain L, Sinclair A, Mann N. Dietary intake of long chain polyunsaturated fatty acids during the Paleolithic. World Rev Nutr Diet 1998; 83:12-23.

Paleo Leadership
Trevor Connor
Trevor Connor

Dr. Loren Cordain’s final graduate student, Trevor Connor, M.S., brings more than a decade of nutrition and physiology expertise to spearhead the new Paleo Diet team.

Mark J Smith
Dr. Mark J. Smith

One of the original members of the Paleo movement, Mark J. Smith, Ph.D., has spent nearly 30 years advocating for the benefits of Paleo nutrition.

Nell Stephenson
Nell Stephenson

Ironman athlete, mom, author, and nutrition blogger Nell Stephenson has been an influential member of the Paleo movement for over a decade.

Loren Cordain
Dr. Loren Cordain

As a professor at Colorado State University, Dr. Loren Cordain developed The Paleo Diet® through decades of research and collaboration with fellow scientists around the world.