Polyunsaturated Fatty Acids | The Paleo Diet®
noun_Search_345985 Created with Sketch.
noun_Search_345985 Created with Sketch.

The latest from The Paleo Diet®, just for you.

Hot topics, new recipes, and science

Polyunsaturated Fatty Acids

By Loren Cordain, Ph.D., Professor Emeritus, Founder of The Paleo Diet
April 18, 2012

Polyunsaturated fatty acids contain two or more double bonds along their carbon backbones. Polyunsaturated fatty acids are classified into two biologically important subgroups: omega-6 and omega-3 fatty acids. Below is a list of the common and numeric names for omega-6 and omega-3 polyunsaturated fatty acids that may occur in foods.

Omega-6 Family Common NameNumeric Name
Linoleic acid18:2n-6
Gamma linolenic acid18:3n-6
Dihomo gamma linolenic acid (DHGLA)20:3n-6
Arachidonic acid20:4n-6
Docosatetraenoic acid22:4n-6
docosapentaenoic acid22:5n-6
Omega-3 Family Common NameNumeric Name
Alpha linoleic acid (ALA)18:3n-3
Parinaric acid18:4n-3
Eicosatetraenoic acid20:4n-3
Eicosapentaenoic acid (EPA)20:5n-3
Docosapentaenoic acid22:5n-3
Docosahexaenoic acid (DHA)22:6n-3

The numeric naming scheme for polyunsaturated fatty acids follows that for saturated and monounsaturated fatty acids. With omega-6 polyunsaturated fatty acids, the last double bond (=) occurs 6 carbon atoms down from the omega or methyl end of the fatty acid, whereas with omega-3 polyunsaturated fatty acids, the last double bond (=) occurs 3 carbon atoms down from the omega end of the fatty acid. In the case of linoleic acid (18:2n-6), there are 18 carbon atoms in the molecule, 2 double bonds (=), and the last double bond is located 6 carbon atoms down from the omega or methyl end of the fatty acid. Below is a schematic diagram of linoleic acid.

Polyunsaturated Fatty Acids image

As was the case with saturated and monounsaturated fatty acids, the schematic diagram above is not precisely correct because it does not show the correct angle of the carbon-to-carbon bonds, which really is 109 degrees rather than 180 degrees. In the diagram below you see a geometrically correct diagram of linoleic acid.

Polyunsaturated Fatty Acids image

Let’s now examine the structure of an omega-3 fatty acid, alpha linolenic acid, or 18:3n-3. There are 18 carbon atoms in the molecule, 3 double bonds (=), and the last double bond is located 3 carbon atoms down from the omega or methyl end of the fatty acid. Below is a schematic diagram of alpha linolenic acid.

Polyunsaturated Fatty Acids image

Alpha linolenic acid (18:3n-3) is the so-called “parent” fatty acid for the omega-3 family of fatty acids because the liver can make other omega-3 fatty acids from it. Similarly, linoleic acid (18:2n-6) is the “parent” fatty acid for the synthesis of other omega-6 fatty acids in the liver. Below is a diagram of how both parent fatty acids can be desaturated and chain elongated in the liver into longer chain polyunsaturated fatty acids.

Polyunsaturated Fatty Acids image

The conversion of dietary 18 carbon polyunsaturated fatty acids (PUFA) to longer chain ( > 20 carbon atoms in length) PUFA is an inefficient process. Only about 6 % of ALA is converted to EPA and less still (0.5 %) is converted to DHA. Because omega-3 and omega-6 parent fatty acids must compete for the same enzymes of desaturation and elongation, a high dietary intake of omega-6 fatty acids (18:2n-6) can further reduce the conversion of ALA to EPA and DHA by 40 to 50 %.

Read the Report

This 2007 review in Applied Physiology of Nutrient Metabolism addresses the question of whether adults can adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?1


There is considerable interest in the potential impact of several polyunsaturated fatty acids (PUFAs) in mitigating the significant morbidity and mortality caused by degenerative diseases of the cardiovascular system and brain. Despite this interest, confusion surrounds the extent of conversion in humans of the parent PUFA, linoleic acid or alpha-linolenic acid (ALA), to their respective long-chain PUFA products. As a result, there is uncertainty about the potential benefits of ALA versus eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Some of the confusion arises because although mammals have the necessary enzymes to make the long-chain PUFA from the parent PUFA, in vivo studies in humans show that asymptotically equal to 5% of ALA is converted to EPA and <0.5% of ALA is converted to DHA. Because the capacity of this pathway is very low in healthy, nonvegetarian humans, even large amounts of dietary ALA have a negligible effect on plasma DHA, an effect paralleled in the omega6 PUFA by a negligible effect of dietary linoleic acid on plasma arachidonic acid. Despite this inefficient conversion, there are potential roles in human health for ALA and EPA that could be independent of their metabolism to DHA through the desaturation - chain elongation pathway.

1. Plourde M, Cunnane SC. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab. 2007 Aug;32(4):619-34.

Even More Articles For You

Evolution and High Protein Diets Part 1
By examining the environment under which our genome arose, we are able to determine if high protein diets are helpful or detrimental to our health.
By Loren Cordain, Ph.D.
The Livable Lifestyle with Lauren: How to Sleep Better After the Time Change
Struggling with daylight savings? Here’s how to get your body to adjust to DST quickly this year, so you can really enjoy that sunlight tradeoff.
By Lauren Fellows
Europe's First Paleo Restaurant
Learn more about Europe's first Paleo Restaurant. The Paleo Diet® is your #1 source for Paleo Diet news, Paleo Diet recipes & more. Browse our site today!
By The Paleo Diet® Team
Paleo Leadership
Trevor Connor
Trevor Connor

Dr. Loren Cordain’s final graduate student, Trevor Connor, M.S., brings more than a decade of nutrition and physiology expertise to spearhead the new Paleo Diet team.

Mark J Smith
Dr. Mark Smith

One of the original members of the Paleo movement, Mark J. Smith, Ph.D., has spent nearly 30 years advocating for the benefits of Paleo nutrition.

Nell Stephenson
Nell Stephenson

Ironman athlete, mom, author, and nutrition blogger Nell Stephenson has been an influential member of the Paleo movement for over a decade.

Loren Cordain
Dr. Loren Cordain

As a professor at Colorado State University, Dr. Loren Cordain developed The Paleo Diet® through decades of research and collaboration with fellow scientists around the world.