I have previously commented upon this single short term mouse study. You are correct in stating the obvious, nowhere in the original article did the authors indicate they were testing a “The Paleo Diet” but rather a low-carbohydrate, high-fat diet in an unusual animal model (prediabetic New Zealand Obese (NZO) mice, rather than in humans.
This single study apparently, seems to be one that the Australian popular press has focused upon and distorted the more far ranging implications of this study. Yet the study totally lacks the criteria and objectivity by which most of the scientific, nutritional community uses to establish cause and effect between diet and disease.
This popular press write-up ignores the most recent human meta analyses (combined studies of all studies) showing the health and weight loss efficacy of randomized controlled trials evaluating contemporary Paleo diets(1). And completely ignores other human studies demonstrating the superiority of Paleo diets to Mediterranean and other diets (2-8).
To establish causality between diet and disease, nutritional scientists employ four basic procedures:
1) human randomized controlled trials
2) four types of human epidemiological studies
3) animal studies and
4) tissue studies.
No single study by itself can establish causality. Rather scientists must present plausible, biological mechanisms and then test these hypotheses using all four procedures with multiple studies (meta analyses) from various laboratories worldwide.
To even suggest, that a single mouse study can be extrapolated to show causality in humans is just bad science. The Australian press should be ashamed of itself for misleading the public.
 Lindeberg S, Jonsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjostrom K, Ahren B: A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia 2007, 50(9):1795-1807. Jönsson T, Granfeldt Y, Ahrén B, Branell UC, Pålsson G, Hansson A, Söderström M, Lindeberg S. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc Diabetol. 2009;8:35
 Jonsson T, Granfeldt Y, Erlanson-Albertsson C, Ahren B, Lindeberg S. A Paleolithic diet is more satiating per calorie than a Mediterranean-like diet in individuals with ischemic heart disease. Nutr Metab (Lond). 2010 Nov 30;7(1):85
 Mellberg C, Sandberg S, Ryberg M, Eriksson M, Brage S, Larsson C, Olsson T, Lindahl B. Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. Eur J Clin Nutr. 2014 Mar;68(3):350-7.
 Boers I, Muskiet FA, Berkelaar E, Schur E, Penders R, Hoenderdos K, Wichers HJ, Jong MC. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome. A randomized controlled pilot-study. Lipids Health Dis. 2014 Oct 11;13:160. doi: 10.1186/1476-511X-13-160.
 Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L. Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. Eur J Clin Nutr. 2015 Apr 1. doi: 10.1038/ejcn.2015.39. [Epub ahead of print]
 Pastore RL, Brooks JT, Carbone JW. Paleolithic nutrition improves plasma lipid concentrations of hypercholesterolemic adults to a greater extent than traditional heart-healthy dietary recommendations. Nutr Res. 2015; 35:474-479.
You can reach me via email if you have any further questions.
Loren Cordain, Ph.D., Professor Emeritus
Department of Health and Exercise Science
Colorado State University
Fort Collins, CO 80523
Dear Dr. Cordain,
How are you? I’m working on a story for Health magazine online (Health.com; the national women’s magazine) regarding this study: http://www.eurekalert.org/pub_releases/2016-02/uom-dew021816.php
We are obviously taking into account that this is a mouse study and the fact that this text doesn’t specifically call out paleo. Since that’s what the release touts, we want to address it and get your perspective on the research. (If there is any issue with the research, what people should know, etc).
Would you be available for a short 10-minute interview tomorrow (Tuesday)? Or if email is better, I can send a few questions that way.
Let me know what you think and many thanks for any help you can offer.