Experimental Autoimmune Encephalomyelitis (EAE)

Experimental Autoimmune Encephalomyelitis (EAE) | The Paleo Diet

This post is a discussion on Experimental Autoimmune Encephalomyelitis (EAE) between Dr. Betty Wedman, a Licensed Nutritionist & Environmental Health Specialist. In his response, Dr. Cordain refers to the paper “A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies,” which is available for download from our web site.

Dr. Cordain,

As a nutrition instructor at 2 Tampa Bay universities, I include the Paleo Diet in my lesson plans frequently and even considering a Nutrition & Anthropology class option. I would like to have more information about the EAE disease study you mentioned at the American Nutraceutical Association Conference 2009.

Thank you.

Betty Wedman

Dr. Cordain’s Response:

Hi Betty,

Many thanks for your support of my work. I’m sorry that we didn’t get to speak to one another directly at the conference. I’m not completely clear on which study I may have mentioned, but I believe it is a study in which EAE (the animal model of MS) was elicited via vaccination with MOG (myelin oligodendrocyte glycoprotein; a known autoantigen in MS) and Quil A as the adjuvant. Quil A is derived from Quillaja, a saponin derived from the bark of a S. American tree and which is a commonly used additive in root beer and soft drinks to make them foam. My point was that the concentration of Quil A used in the mouse study can be achieved via consumption of root beer and that resident E. Coli contain an epitope similar in structure to MOG. Hence it may be possible to elicit autoimmune diseases via unintentionally mucosal vaccination via certain dietary adjuvants (saponins) in naturally occurring foods along with mimicking epitopes derived from resident gut flora.


Loren Cordain, Ph.D., Professor Emeritus

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About the Author:

Loren Cordain, PhD, Professor Emeritus Dr. Loren Cordain is Professor Emeritus of the Department of Health and Exercise Science at Colorado State University in Fort Collins, Colorado. His research emphasis over the past 20 years has focused upon the evolutionary and anthropological basis for diet, health and well being in modern humans. Dr. Cordain’s scientific publications have examined the nutritional characteristics of worldwide hunter-gatherer diets as well as the nutrient composition of wild plant and animal foods consumed by foraging humans. He is the world’s leading expert on Paleolithic diets and has lectured extensively on the Paleolithic nutrition worldwide. Dr. Cordain is the author of six popular bestselling books including The Real Paleo Diet Cookbook, The Paleo Diet, The Paleo Answer, and The Paleo Diet Cookbook, summarizing his research findings.

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