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Category Archives: 2006
Paleolithic Diet Confers Higher Insulin Sensitivity, Lower C-Reactive Protein and Lower Blood Pressure Than a Cereal-Based Diet
Coronary Artery Disease Prognosis and C Reactive Protein-Levels Improve in Proportion to Percent Lowering of Low Density Lipoprotein
Ultraviolet Radiation Represents an Evolutionary Selective Pressure for the South-to-North Gradient of the MTHFR 677TT Genotype
Saturated Fat Consumption in Ancestral Human Diets
Implications of Plio-Pleistocene Hominin Diets for Modern Humans
Dietary Implications for the Development of Acne: A Shifting Paradigm
O’Keefe JH Jr, Cordain L, Jones PG, Abuissa H. Coronary artery disease prognosis and C-reactive protein levels improve in proportion to percent lowering of low-density lipoprotein. Am J Cardiol. 2006 Jul 1;98(1):135-9.
ABSTRACT This editorial outlines the data supporting aggressive lipid goals and options for treating low-density lipoprotein (LDL) cholesterol to a range of approximately 30 to 70 mg/dl. The physiologically normal cholesterol range is approximately 30 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and virtually all wild mammals. Randomized statin trials in patients with recent acute coronary syndromes and stable coronary artery disease have demonstrated that cardiovascular events are reduced and cardiovascular survival optimized when LDL cholesterol is reduced to <70 mg/dl. Secondary prevention trials have shown a decrease in all-cause mortality in proportion to the magnitude…
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