Most nutrition students know that dietary proteins are not absorbed by the intestines because they are broken down into their component amino acids by enzymes in the gut during the digestive process. Even if dietary proteins escape proteolytic (protein shearing) degradation in the gut, they are normally denied entry into the bloodstream by various gut, liver and immune system barriers. For the past 20 years the pharmaceutical industry has been keenly interested in figuring out a way in which to get intact proteins past the gut barrier and into the bloodstream — and rightly so. A billion dollar market would be instantly opened up to any company that could develop a procedure
to transport insulin (a large protein molecule) across the gut barrier without directly injecting it into the bloodstream. An insulin pill would be a diabetic patient’s dream come true. Well guess what? The day in which an insulin pill will become a reality is getting closer. As a Paleo Diet fan, you may be scratching your head and saying, “So-what – why should I be interested in an insulin pill. Shouldn’t proper diet and exercise be the preferred approach for treating type 2 diabetics?” You are absolutely correct, but the relevance of the insulin pill or Paleo Diet devotees is not to be necessarily found in the clinical application, but rather in the pathway whereby intact proteins gain access to the bloodstream. This pathway and its nutritional ramifications represent one of the most fascinating and relevant evolutionary tales in all of human history. Read more…
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